UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Incidence and significance of an elevated red blood cell distribution width among hospitalised HIV-infected adult patients

Dissanayake, O; Merriman, RC; Alnajar, S; Hunter, A; Burns, F; Miller, RF; (2019) Incidence and significance of an elevated red blood cell distribution width among hospitalised HIV-infected adult patients. International Journal of STD & AIDS 10.1177/0956462419851903. Green open access

[img]
Preview
Text
Miller RDW.pdf - Accepted version

Download (686kB) | Preview

Abstract

We audited the records of unselected hospitalised HIV-positive adults admitted to a University-affiliated inner London hospital to identify the frequency of elevated red blood cell distribution width (RDW), and potential associations with specific diagnoses, and with outcome. Of 259 patients audited, 188 (73%) were men. Patients' median age was 47 years (interquartile range = 41-54). An elevated RDW was seen in 50 patients (19%); 200 (77%) had an elevated C-reactive protein (CRP), and 77 (30%) had a low haemoglobin. Only five patients had an elevated RDW without an elevated CRP and/or low haemoglobin. An elevated RDW was associated with a wide range of infectious, inflammatory, and malignant conditions similar to observed associations reported in the general non-HIV infected adult population. Additionally an elevated RDW occurred both in patients with well-controlled HIV infection and in receipt of antiretroviral therapy, as well as in those with newly diagnosed and poorly-controlled infection. Five (10%) of 50 patients with an elevated RDW needed intensive care unit (ICU) admission and two (4%) died. Two (0.95%) of 209 patients with a normal RDW needed ICU admission and four (1.9%) died. The findings of this audit are limited by the relatively small number of patients and the single site nature of the audit.

Type: Article
Title: Incidence and significance of an elevated red blood cell distribution width among hospitalised HIV-infected adult patients
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0956462419851903
Publisher version: https://doi.org/10.1177/0956462419851903
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: HIV infection, Red blood cell distribution width, anisocytosis, inflammation, malignancy, outcome
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10077420
Downloads since deposit
77Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item