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Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule

Martinez-Corrales, G; Cabrero, P; Dow, JAT; Terhzaz, S; Davies, S-A; (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development , 146 , Article dev178087. 10.1242/dev.178087. Green open access

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Abstract

The GATA family of transcription factors is implicated in numerous developmental and physiological processes in metazoans. In Drosophila melanogaster, five different GATA factor genes ( pannier, serpent, grain, GATAd and GATAe) have been reported as essential in the development and identity of multiple tissues, including the midgut, heart and brain. Here, we present a novel role for GATAe in the function and homeostasis of the Drosophila renal (Malpighian) tubule. We demonstrate that reduced levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration of renal and nephritic stem cells into the tubule. Our findings of GATAe as a potential master regulator in the events of growth control and cell survival required for the maintenance of the Drosophila renal tubule could provide new insights into the molecular pathways involved in the formation and maintenance of a functional tissue and kidney disease.

Type: Article
Title: Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dev.178087
Publisher version: https://doi.org/10.1242/dev.178087
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: GATAe, Drosophila, Malpighian tubules, Principal and stellate cells, Renal stem cells, Proliferation, Maintenance, Migration
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10077417
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