Harrison, PJ;
Tunbridge, EM;
Dolphin, AC;
Hall, J;
(2020)
Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.
The British Journal of Psychiatry
, 216
(5)
pp. 250-253.
10.1192/bjp.2019.157.
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Abstract
We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.
| Type: | Article |
|---|---|
| Title: | Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1192/bjp.2019.157 |
| Publisher version: | https://doi.org/10.1192/bjp.2019.157 |
| Language: | English |
| Additional information: | This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Calcium channels; therapy; psychiatry; bipolar affective disorders; novel central nervous system drugs. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10077291 |
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