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Clinical presentation and neuropsychological profiles of Functional Cognitive Disorder patients with and without co-morbid depression

Bhome, R; Huntley, JD; Price, G; Howard, RJ; (2019) Clinical presentation and neuropsychological profiles of Functional Cognitive Disorder patients with and without co-morbid depression. Cognitive Neuropsychiatry , 24 (2) pp. 152-164. 10.1080/13546805.2019.1590190. Green open access

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Abstract

INTRODUCTION: Functional Cognitive Disorder (FCD) is poorly understood. We sought to better characterise FCD in order to inform future diagnostic criteria and evidence based treatments. Additionally, we compared FCD patients with and without co-morbid depression, including their neuropsychological profiles, to determine whether these two disorders are distinct. METHODS: 47 FCD patients (55% female, mean age: 52 years) attending a tertiary neuropsychiatric clinic over a one year period were included. We evaluated sociodemographic characteristics and clinical features including presentation, medications, the presence and nature of co-morbid psychiatric or physical illnesses, and the results of neuropsychometric testing. RESULTS: 23/47 (49%) patients had co-morbid depression. Six had cognitive difficulties greater than expected from their co-morbid conditions suggesting “functional overlay”. 34 patients had formal neuropsychological testing; 12 demonstrated less than full subjective effort. 16/22 (73%) of the remaining patients had non-specific cognitive impairment in at least one domain. There were no significant differences between those with and without co-morbid depression. CONCLUSIONS: Our study informs future diagnostic criteria. For example, they should not exclude patients with co-morbid psychiatric illness or abnormal neuropsychometric testing and clinicians should remain open to the possibility of “functional overlay”. Furthermore, FCD and depression are distinct disorders that can exist co-morbidly.

Type: Article
Title: Clinical presentation and neuropsychological profiles of Functional Cognitive Disorder patients with and without co-morbid depression
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/13546805.2019.1590190
Publisher version: https://doi.org/10.1080/13546805.2019.1590190
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Functional Cognitive Disorder, clinical characteristics, neuropsychometry, memory clinic, depression
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10077243
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