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Cell fate decisions during development

Mayor, R; (2019) Cell fate decisions during development. Science , 364 (6444) pp. 937-938. 10.1126/science.aax7917. Green open access

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Abstract

This revised vision for neural crest cell differentiation is consistent with what has been proposed for the differentiation of other cell types, such as those of the hematopoietic lineage (13). The first stable bifurcation identified in neural crest differentiation separates progenitors of the sensory lineage from those of autonomic and mesenchymal fates. This is followed by additional binary decisions that separate autonomic neuronal fate from mesenchymal differentiation. This contrasts with the current view in which a single precursor differentiates directly into specific cell types. In addition, Soldatov et al. show that many transcription factors considered as “master regulators” for specific lineages are not expressed at the time of the bifurcation to differentiate into these three lineages. This suggests that the activation of specific gene expression programs around the bifurcation point is triggered not by these master regulators, but by environmental conditions, such as chemical or mechanical cues (3, 14).

Type: Article
Title: Cell fate decisions during development
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.aax7917
Publisher version: https://doi.org/10.1126/science.aax7917
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Animals, Cell Differentiation, Cell Lineage, Mice, Neural Crest
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10077227
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