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Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis

Godazandeh, K; Martinez Sosa, S; Wu, J; Zakrzewska, JM; (2019) Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis. Multiple Sclerosis and Related Disorders , 34 pp. 41-46. 10.1016/j.msard.2019.06.015. Green open access

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Abstract

OBJECTIVES: The commonest secondary cause for trigeminal neuralgia (TN) is multiple sclerosis (MS) and little is known about this group of patients in terms of their presentation and treatments. We compared patients with TN and MS (pwTNMS) with a cohort of patients with primary TN, who had been referred to the same specialist unit, both in terms of characteristics and impact on quality of life at the time of their first assessment. // METHODS: Using a prospective patient database we extracted key clinical data and results from psychometrically tested questionnaires of 26 pwTNMS and compared them to an age and gender-matched set of 68 patients with primary TN. // RESULTS: Our findings suggest that pwTNMS exhibit a more severe clinical phenotype than primary TN. Prior to referral, pwTNMS are more likely to have used more healthcare services and undergone more neurosurgical interventions. Strikingly, pwTNMS exhibit reduced lengths and duration of remission periods and fewer identifiable triggers. Furthermore, pwTNMS report significant impact on quality of life comparable to those in primary TN, scoring highly in measures of anxiety, depression, and catastrophizing, but also report greater sleep disturbance, and overall interference in activities of daily living. // CONCLUSIONS: pwTNMS have a more intractable TN, one which may necessitate a more complex approach to treatment, earlier referral to secondary care and an extensive assessment of mental health. Quality of life in pwTNMS is severely affected by both their MS and their TN, suggesting management should occur in specialist centres with access to a multidisciplinary team.

Type: Article
Title: Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.msard.2019.06.015
Publisher version: https://doi.org/10.1016/j.msard.2019.06.015
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Case control, Multiple sclerosis, Trigeminal neuralgia
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10077168
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