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Mouse models of neurodegeneration: Know your question, know your mouse

Fisher, EMC; Bannerman, DM; (2019) Mouse models of neurodegeneration: Know your question, know your mouse. Science Translational Medicine , 11 (493) , Article eaaq1818. 10.1126/scitranslmed.aaq1818. Green open access

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Abstract

Many mutant mouse strains have been developed as models to investigate neurodegenerative disease in humans. However, variability in results among studies using these mouse strains has led to questions about the value of these models. Here, we appraise various mouse models for dissecting neurodegenerative disease mechanisms and emphasize the importance of asking appropriate research questions. In therapeutic studies, we suggest that understanding variability among and within mouse models is crucial for preventing translational failures in human patients.

Type: Article
Title: Mouse models of neurodegeneration: Know your question, know your mouse
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/scitranslmed.aaq1818
Publisher version: https://doi.org/10.1126/scitranslmed.aaq1818
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10077012
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