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Dabrafenib in BRAFV600-mutated anaplastic pleomorphic xanthoastrocytoma

Brown, NF; Carter, T; Mulholland, P; (2017) Dabrafenib in BRAFV600-mutated anaplastic pleomorphic xanthoastrocytoma. CNS Oncology , 6 (1) 10.2217/cns-2016-0031. Green open access

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Abstract

Pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor. Anaplastic features are found in 20-30% of cases of PXA and are associated with poor outcomes. Typical treatment is with gross total resection, followed by radiation therapy and cytotoxic chemotherapy at relapse. BRAFV600 mutations have been identified in 38-60% of patients with PXA. Several case reports and small case series have identified clinical benefit with BRAF inhibition in patients with BRAFV600-mutated PXA. We report the second published case of successful treatment with the BRAF inhibitor dabrafenib in a female patient with relapsed anaplastic PXA with a BRAFV600 mutation, and the first published case of dabrafinib treatment following intolerance to vemurafenib.

Type: Article
Title: Dabrafenib in BRAFV600-mutated anaplastic pleomorphic xanthoastrocytoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/cns-2016-0031
Publisher version: https://doi.org/10.2217/cns-2016-0031
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: anaplastic, BRAF inhibitor, BRAFV600 mutation, dabrafenib, pleomorphic xanthoastrocytoma, PXA, vemurafenib
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10076956
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