Brown, NF;
Carter, TJ;
Ottaviani, D;
Mulholland, P;
(2018)
Harnessing the immune system in glioblastoma.
British Journal of Cancer
, 119
(10)
pp. 1171-1181.
10.1038/s41416-018-0258-8.
Preview |
Text
Harnessing the immune system in glioblastoma.pdf - Published Version Download (1MB) | Preview |
Abstract
Glioblastoma is the most common primary malignant brain tumour. Survival is poor and improved treatment options are urgently needed. Although immunotherapies have emerged as effective treatments for a number of cancers, translation of these through to brain tumours is a distinct challenge, particularly due to the blood–brain barrier and the unique immune tumour microenvironment afforded by CNS-specific cells. This review discusses the immune system within the CNS, mechanisms of immune escape employed by glioblastoma, and the immunological effects of conventional glioblastoma treatments. Novel therapies for glioblastoma that harness the immune system and their current clinical progress are outlined, including cancer vaccines, T-cell therapies and immune checkpoint modulators.
| Type: | Article |
|---|---|
| Title: | Harnessing the immune system in glioblastoma |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41416-018-0258-8 |
| Publisher version: | https://doi.org/10.1038/s41416-018-0258-8 |
| Language: | English |
| Additional information: | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creative commons.org/licenses/by/4.0/. |
| Keywords: | oncology, central-nervous-system, tumor-associated macrophages, newly-diagnosed glioblastoma, high-grade glioma, anti-angiogenic therapy, regulatory t-cells, growth-factor-beta, cancer stem-cells, brain-tumors, recurrent glioblastoma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10076954 |
Archive Staff Only
 |
View Item |
