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High-resolution anal manometry: Repeatability, validation, and comparison with conventional manometry

Gosling, J; Plumb, A; Taylor, SA; Cohen, R; Emmanuel, A; (2019) High-resolution anal manometry: Repeatability, validation, and comparison with conventional manometry. Neurogastroenterology & Motility , 31 (6) , Article e13591. 10.1111/nmo.13591. Green open access

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Abstract

BACKGROUND: Accurate measurement of anal sphincter function is potentially of value in defining treatment of common pelvic floor disorders. The aim of this study was to establish repeatability and validate high‐resolution anorectal manometry (HRAM) by comparison to conventional manometry (CM). Arising from this work would be definitive normal range data. METHODS: Eighty healthy volunteers (40 female) underwent a test‐retest repeatability study. A 16‐channel water‐perfused HRAM catheter was compared to an 8‐channel conventional catheter using a station pull‐through technique. KEY RESULTS: High‐resolution anorectal manometry had similar precision to conventional manometry when measuring resting pressure (intraclass correlation coefficient [ICC] 0.73 vs 0.68, HRAM vs CM) and squeeze increment (ICC 0.90 vs 0.94, HRAM vs CM). HRAM measured resting pressures 10% lower than CM and squeeze pressure 27% higher than CM. CONCLUSION AND INTERFERENCE: High‐resolution anorectal manometry is a valid technique with comparable precision to CM. HRAM measurements differ considerably to CM, and a new set of normal values must be used.

Type: Article
Title: High-resolution anal manometry: Repeatability, validation, and comparison with conventional manometry
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nmo.13591
Publisher version: https://doi.org/10.1111/nmo.13591
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: anorectal manometry, fecal incontinence, pelvic floor dysfunction, test validation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10076920
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