Khan, MF;
Spurgeon, SK;
Nofal, MM;
Yan, X-G;
(2019)
Semi-Disparate Impact of Kinases GCN2 and PERK in Modulating the Dynamic Control Properties of eIF2 Pathway.
IEEE Access
, 7
pp. 68132-68139.
10.1109/ACCESS.2019.2918216.
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Abstract
The tumor microenvironment associated with deficiencies in nutrients and oxygen is important in observing the regulation of tumor progression. The aggressiveness of the tumor cells can be stimulated by exposing it to nutrient starvation and hypoxia. During nutrient starvation, activation of an integrated stress response pathway takes place, which helps tumor cells to cope with nutrient stress. In this paper, an evolutionarily conserved central translational control pathway, i.e., the integrated stress response pathway is analyzed with the help of a mathematical model. This paper is of significant novelty in terms of testable predictions about specific pathway properties with the help of analysis tools from control theory. The investigation has suggested that both kinases GCN2 and PERK have semi-disparate impact on the dynamic control properties of the system. The examples include both kinases show analogous behavior toward the robustness and stability of the system, but disparate behavior in compensating the loss of another kinase.
| Type: | Article |
|---|---|
| Title: | Semi-Disparate Impact of Kinases GCN2 and PERK in Modulating the Dynamic Control Properties of eIF2 Pathway |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/ACCESS.2019.2918216 |
| Publisher version: | https://doi.org/10.1109/ACCESS.2019.2918216 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Technology, Computer Science, Information Systems, Engineering, Electrical & Electronic, Telecommunications, Computer Science, Engineering, Bode analysis, linear system, mathematical modeling, protein synthesis, robustness, stability, biophysics, GUANINE-NUCLEOTIDE EXCHANGE, TRANSLATION INITIATION, EIF2-ALPHA KINASES, PROTEIN-SYNTHESIS, MECHANISMS, BINDING, PHOSPHORYLATION, ACTIVATION, SYSTEM, YEAST |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10076865 |
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