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The role of gut hormones in the pathogenesis and management of obesity

Makaronidis, JM; Batterham, RL; (2019) The role of gut hormones in the pathogenesis and management of obesity. [Review]. Current Opinion in Physiology , 12 pp. 1-11. 10.1016/j.cophys.2019.04.007. Green open access

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Abstract

The growing obesity epidemic is driving the need for development of novel, effective therapeutic strategies for obesity and its complications. Increasing our understanding of the processes controlling body weight is therefore imperative. Gut hormones have emerged as essential regulators of energy homeostasis. Dysregulation of gut hormone physiology is increasingly implicated in obesity pathogenesis and the compensatory biological responses driving weight regain following energy restriction. Furthermore, gut hormones are among key mediators of the weight loss following Rouxen-Y gastric bypass and sleeve gastrectomy, the bariatric procedures which remain the most effective treatment for severe obesity. Therapeutic strategies targeting gut hormones and their receptors are driving a new pharmacotherapy era and constitute the most promising approach to addressing the obesity epidemic.

Type: Article
Title: The role of gut hormones in the pathogenesis and management of obesity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cophys.2019.04.007
Publisher version: https://doi.org/10.1016/j.cophys.2019.04.007
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: obesity, gut hormones, weight loss, ghrelin, GLP-1, PYY
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10076826
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