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Wnt Signaling Deregulation in the Aging and Alzheimer's Brain

Palomer, E; Buechler, J; Salinas, PC; (2019) Wnt Signaling Deregulation in the Aging and Alzheimer's Brain. Frontiers in Cellular Neuroscience , 13 , Article 227. 10.3389/fncel.2019.00227. Green open access

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Abstract

Growing evidence suggests that synaptic signaling is compromised in the aging brain and in Alzheimer’s disease (AD), contributing to synaptic decline. Wnt signaling is a prominent pathway at the synapse and is required for synaptic plasticity and maintenance in the adult brain. In this review, we summarize the current knowledge on deregulation of Wnt signaling in the context of aging and AD. Emerging studies suggest that enhancing Wnt signaling could boost synaptic function during aging, and ameliorate synaptic pathology in AD. Although further research is needed to determine the precise contribution of deficient Wnt signaling to AD pathogenesis, targeting Wnt signaling components may provide novel therapeutic avenues for synapse protection or restoration in the brain.

Type: Article
Title: Wnt Signaling Deregulation in the Aging and Alzheimer's Brain
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fncel.2019.00227
Publisher version: https://doi.org/10.3389/fncel.2019.00227
Language: English
Additional information: Copyright © 2019 Palomer, Buechler and Salinas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: Wnt, aging brain, synapse degeneration, synaptic maintenance, Alzheimer’s disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10076643
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