George, J;
Hsu, CC;
Nguyen, LTB;
Ye, H;
Cui, Z;
(2019)
Neural tissue engineering with structured hydrogels in CNS models and therapies.
Biotechnology Advances
10.1016/j.biotechadv.2019.03.009.
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Abstract
The development of techniques to create and use multiphase microstructured hydrogels (granular hydrogels or microgels) has enabled the generation of cultures with more biologically relevant architecture and use of structured hydrogels is especially pertinent to the development of new types of central nervous system (CNS) culture models and therapies. We review material choice and the customisation of hydrogel structure, as well as the use of hydrogels in developmental models. Combining the use of structured hydrogel techniques with developmentally relevant tissue culture approaches will enable the generation of more relevant models and treatments to repair damaged CNS tissue architecture.
| Type: | Article |
|---|---|
| Title: | Neural tissue engineering with structured hydrogels in CNS models and therapies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.biotechadv.2019.03.009 |
| Publisher version: | https://doi.org/10.1016/j.biotechadv.2019.03.009 |
| Language: | English |
| Additional information: | © 2019 Elsevier Inc. Open Access. Licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/ by/4.0/). |
| Keywords: | Extracellular matrix, Neuron, Structured Hydrogel, Microgel, Granular hydrogel, Tissue Engineering, Regenerative Medicine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10076637 |
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