UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Neural crest Notch/Rbpj signaling regulates olfactory gliogenesis and neuronal migration

Miller, SR; Benito, C; Mirsky, R; Jessen, KR; Baker, CVH; (2018) Neural crest Notch/Rbpj signaling regulates olfactory gliogenesis and neuronal migration. Genesis , 56 (6-7) , Article e23215. 10.1002/dvg.23215. Green open access

[img]
Preview
Text
Miller_et_al-2018-genesis.pdf - Published version

Download (2MB) | Preview

Abstract

The neural crest‐derived ensheathing glial cells of the olfactory nerve (OECs) are unique in spanning both the peripheral and central nervous systems: they ensheathe bundles of axons projecting from olfactory receptor neurons in the nasal epithelium to their targets in the olfactory bulb. OECs are clinically relevant as a promising autologous cell transplantation therapy for promoting central nervous system repair. They are also important for fertility, being required for the migration of embryonic gonadotropin‐releasing hormone (GnRH) neurons from the olfactory placode along terminal nerve axons to the medial forebrain, which they enter caudal to the olfactory bulbs. Like Schwann cell precursors, OEC precursors associated with the developing olfactory nerve express the glial marker myelin protein zero and the key peripheral glial transcription factor Sox10. The transition from Schwann cell precursors to immature Schwann cells is accelerated by canonical Notch signaling via the Rbpj transcription factor. Here, we aimed to test the role of Notch/Rbpj signaling in developing OECs by blocking the pathway in both chicken and mouse. Our results suggest that Notch/Rbpj signaling prevents the cranial neural crest cells that colonize the olfactory nerve from differentiating as neurons, and at later stages contributes to the guidance of GnRH neurons.

Type: Article
Title: Neural crest Notch/Rbpj signaling regulates olfactory gliogenesis and neuronal migration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/dvg.23215
Publisher version: https://doi.org/10.1002/dvg.23215
Language: English
Additional information: © 2018 The Authors Genesis: The Journal of Genetics and Development Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: chicken embryo , gonadotropin‐releasing hormone (GnRH) neurons, mouse embryo, olfactory ensheathing glial cell
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10076634
Downloads since deposit
53Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item