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Accuracy of tests used to detect infection with Chlamydia trachomatis in asymptomatic pregnant women: a systematic review

Sahi, S-V; Rogozińska, E; Sobhy, S; Khan, KS; (2017) Accuracy of tests used to detect infection with Chlamydia trachomatis in asymptomatic pregnant women: a systematic review. Current Opinion in Obstetrics and Gynecology , 29 (6) pp. 375-382. 10.1097/GCO.0000000000000411. Green open access

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Abstract

PURPOSE OF REVIEW: Infection with Chlamydia trachomatis in pregnancy is linked to increased risk of miscarriage, stillbirth, and preterm birth. Currently, PCR or DNA-based tests are the gold standard when detecting the infection; however, they are costly and require access to specialist equipment. The aim of this systematic review was to assess the accuracy of available tests to detect infection in an asymptomatic pregnant population. RECENT FINDINGS: There was evidence of the superior accuracy of nucleic acid amplification tests to cell culture in nonpregnant asymptomatic women; however, there are multiple commercial nucleic acid amplification tests with varying sensitivities and specificities. There is a gap in current literature on accuracy studies in an asymptomatic pregnant population, particularly within routine antenatal settings. SUMMARY: There is a need for a point-of-care test for Chlamydia in pregnancy. Future test accuracy studies for this population should aim to use a universally established reference standard. Further research should provide relevant evidence to guide practice.

Type: Article
Title: Accuracy of tests used to detect infection with Chlamydia trachomatis in asymptomatic pregnant women: a systematic review
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/GCO.0000000000000411
Publisher version: https://journals.lww.com/co-obgyn/Fulltext/2017/12...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Chlamydia Infections, Chlamydia trachomatis, Diagnostic Techniques and Procedures, Female, Humans, Nucleic Acid Amplification Techniques, Point-of-Care Testing, Predictive Value of Tests, Pregnancy, Pregnancy Complications, Infectious, Prenatal Care
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10076441
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