A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins

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A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins

Pless, SA; Sivilotti, LG; (2018) A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins. Current Opinion in Physiology , 2 pp. 19-26. 10.1016/j.cophys.2017.12.012. Green open access

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Abstract

Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all Bilateria and in several groups of bacteria and archaea. They are activated by small-molecule neurotransmitters to mediate fast neurotransmission at many central and peripheral synapses and are the target of several drugs and insecticides. Here we review recent advances in the field, focussing on new insights on the structure of the agonist-binding site and on newly discovered protein–protein interactions involving pLGICs.

Type:	Article
Title:	A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1016/j.cophys.2017.12.012
Publisher version:	https://doi.org/10.1016/j.cophys.2017.12.012
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification:	UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI:	https://discovery.ucl.ac.uk/id/eprint/10076408

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