UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data

Breeze, CE; Reynolds, AP; van Dongen, J; Dunham, I; Lazar, J; Neph, S; Vierstra, J; ... Beck, S; + view all (2019) eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data. Bioinformatics 10.1093/bioinformatics/btz456. (In press). Green open access

[img]
Preview
Text
Beck_eFORGE v2.0. updated analysis of cell type-specific signal in epigenomic data_AOP.pdf - Published version

Download (471kB) | Preview

Abstract

SUMMARY: The Illumina Infinium EPIC BeadChip is a new high-throughput array for DNA methylation analysis, extending the earlier 450k array by over 400,000 new sites. Previously, a method named eFORGE was developed to provide insights into cell type-specific and cell composition effects for 450k data. Here, we present a significantly updated and improved version of eFORGE that can analyse both EPIC and 450k array data. New features include analysis of chromatin states, TF motifs and DNase I footprints, providing tools for EWAS interpretation and epigenome editing. AVAILABILITY: eFORGE v2.0 is implemented as a web tool available from https://eforge.altiusinstitute.org and https://eforge-tf.altiusinstitute.org/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Type: Article
Title: eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/bioinformatics/btz456
Publisher version: https://doi.org/10.1093/bioinformatics/btz456
Language: English
Additional information: © The Author(s) 2019. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/10076274
Downloads since deposit
19Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item