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The origin of platelets enabled the evolution of eutherian placentation

Martin, JF; Wagner, GP; (2019) The origin of platelets enabled the evolution of eutherian placentation. Biology Letters , 15 (7) , Article 20190374. 10.1098/rsbl.2019.0374. Green open access

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Abstract

Invasive placentation with extended pregnancy is a shared derived characteristic unique to eutherian mammals that possess a highly effective system of haemostasis, platelets. These are found in all mammals but no other group of animals. We propose that platelets and megakaryocytes (large polyploid nucleated bone marrow cells that produce platelets) evolved from an ancestral 2 N thrombocyte by polyploidization and that the possession of platelets enabled the evolution of invasive placentation. This could explain why invasive placentation is limited to mammals.

Type: Article
Title: The origin of platelets enabled the evolution of eutherian placentation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rsbl.2019.0374
Publisher version: https://doi.org/10.1098/rsbl.2019.0374
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10076076
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