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A new strategy for vascular complications in young people with type 1 diabetes mellitus

Marcovecchio, ML; Dalton, RN; Daneman, D; Deanfield, J; Jones, TW; Neil, HAW; Dunger, DB; (2019) A new strategy for vascular complications in young people with type 1 diabetes mellitus. Nature Reviews Endocrinology , 15 pp. 429-235. 10.1038/s41574-019-0198-2. Green open access

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Abstract

Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic control and consequent increased HbA1c levels are major risk factors for the development of vascular complications. HbA1c levels are the main focus of current management strategies; however, the recommended target is rarely achieved in adolescents. Thus, a clear need exists for improved biomarkers to identify high-risk young people early and to develop new intervention strategies. Evidence is accumulating that early increases in urinary albumin excretion could be predictive of adolescents with T1DM who are at an increased risk of developing vascular complications, independent of HbA1c levels. These findings present an opportunity to move towards the personalized care of adolescents with T1DM, which takes into consideration changes in albumin excretion and other risk factors in addition to HbA1c levels.

Type: Article
Title: A new strategy for vascular complications in young people with type 1 diabetes mellitus
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41574-019-0198-2
Publisher version: https://doi.org/10.1038/s41574-019-0198-2
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Diabetes, Diabetes complications, Paediatrics
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10076016
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