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Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves

Jessen, KR; Mirsky, R; (2019) Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves. Frontiers in Molecular Neuroscience , 12 , Article 69. 10.3389/fnmol.2019.00069. Green open access

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Abstract

The cells of the neural crest, often referred to as neural crest stem cells, give rise to a number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves. Crest cells transform to adult Schwann cells through the generation of two well defined intermediate stages, the Schwann cell precursors (SCP) in early embryonic nerves, and immature Schwann cells (iSch) in late embryonic and perinatal nerves. SCP are formed when neural crest cells enter nascent nerves and form intimate relationships with axons, a diagnostic feature of glial cells. This involves large-scale changes in gene expression, including the activation of established glial cell markers. Like early glia in the CNS, radial glia, SCP retain developmental multipotency and contribute to other crest-derived lineages during embryonic development. SCP, as well as closely related cells termed boundary cap cells, and later stages of the Schwann cell lineage have all been implicated as the tumor initiating cell in NF1 associated neurofibromas. iSch are formed from SCP in a process that involves the appearance of additional differentiation markers, autocrine survival circuits, cellular elongation, a formation of endoneurial connective tissue and basal lamina. Finally, in peri- and post-natal nerves, iSch are reversibly induced by axon-associated signals to form the myelin and non-myelin Schwann cells of adult nerves. This review article discusses early Schwann cell development in detail and describes a large number of molecular signaling systems that control glial development in embryonic nerves.

Type: Article
Title: Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fnmol.2019.00069
Publisher version: https://doi.org/10.3389/fnmol.2019.00069
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Schwann cell precursor, neural crest, nerve development, PNS, Schwann cell lineage, PNS glia, multipotent glia, BOUNDARY CAP CELLS, CREST STEM-CELLS, TRANSCRIPTION FACTOR SOX10, NEURAL CREST, PERIPHERAL-NERVES, NERVOUS-SYSTEM, GROWTH-FACTOR, IN-VITRO, NEURONAL DIFFERENTIATION, DESERT-HEDGEHOG
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10075902
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