Vivekananda, U;
Bush, D;
Bisby, JA;
Diehl, B;
Jha, A;
Nachev, P;
Rodionov, R;
... Walker, MC; + view all
(2019)
Spatial and episodic memory tasks promote temporal lobe interictal spikes.
Annals of Neurology
10.1002/ana.25519.
(In press).
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Abstract
Reflex epilepsies have been demonstrated to exploit specific networks that subserve normal physiological function. It is unclear whether more common forms of epilepsy share this particular feature. By measuring interictal spikes in patients with a range of epilepsies, we show that two tasks known to specifically engage the hippocampus and temporal neocortex promote increased interictal spiking within these regions, whilst a non‐hippocampal dependent task did not. This indicates that interictal spike frequency may reflect the processing demands being placed on specific functional‐anatomical networks in epilepsy.
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