UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers

Sheppard, T; Laserna, V; Jeapes Rojas, C; (2019) Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers. Organic Letters , 21 (12) pp. 4443-4447. 10.1021/acs.orglett.9b01208. Green open access

[thumbnail of HydrophenoxylationRevised.pdf]
Preview
Text
HydrophenoxylationRevised.pdf - Accepted Version

Download (565kB) | Preview

Abstract

A practical method for the synthesis of phenyl enol ethers is reported. The combination of a gold(I) catalyst and potassium carbonate selectively mediates the addition of phenols to propargylic alcohols/amines in a chemo-, regio-, and stereoselective fashion in high yield. The resulting enol ethers are formed exclusively with a Z-configuration and can be obtained from a wide array of phenols and propargylic alcohols or amines with the reaction showing excellent functional group tolerance.

Type: Article
Title: Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.orglett.9b01208
Publisher version: https://doi.org/10.1021/acs.orglett.9b01208
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10075824
Downloads since deposit
97Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item