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Pericytes in Muscular Dystrophies

Moyle, LA; Tedesco, FS; Benedetti, S; (2019) Pericytes in Muscular Dystrophies. Advances in Experimental Medicine and Biology , 1147 pp. 319-344. 10.1007/978-3-030-16908-4_15. Green open access

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Abstract

The muscular dystrophies are an heterogeneous group of inherited myopathies characterised by the progressive wasting of skeletal muscle tissue. Pericytes have been shown to make muscle in vitro and to contribute to skeletal muscle regeneration in several animal models, although recent data has shown this to be controversial. In fact, some pericyte subpopulations have been shown to contribute to fibrosis and adipose deposition in muscle. In this chapter, we explore the identity and the multifaceted role of pericytes in dystrophic muscle, potential therapeutic applications and the current need to overcome the hurdles of characterisation (both to identify pericyte subpopulations and track cell fate), to prevent deleterious differentiation towards myogenic-inhibiting subpopulations, and to improve cell proliferation and engraftment efficacy.

Type: Article
Title: Pericytes in Muscular Dystrophies
ISBN-13: 978-3-030-16907-7
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-030-16908-4_15
Publisher version: https://doi.org/10.1007/978-3-030-16908-4_15
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Adipogenesis, Cell therapy, Chondrogenesis, Fibrosis, Muscle, Muscle regeneration, Muscular dystrophy, Pericytes, Plasticity, Stem cells
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10075578
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