Anderson, SL;
Boyd, PG;
Gladysiak, A;
Nguyen, TN;
Palgrave, RG;
Kubicki, D;
Emsley, L;
... Stylianou, KC; + view all
(2019)
Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor.
Nature Communications
, 10
, Article 1612. 10.1038/s41467-019-09486-2.
(In press).
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Abstract
Biologically derived metal-organic frameworks (bio-MOFs) are of great importance as they can be used as models for bio-mimicking and in catalysis, allowing us to gain insights into how large biological molecules function. Through rational design, here we report the synthesis of a novel bio-MOF featuring unobstructed Watson-Crick faces of adenine (Ade) pointing towards the MOF cavities. We show, through a combined experimental and computational approach, that thymine (Thy) molecules diffuse through the pores of the MOF and become base-paired with Ade. The Ade-Thy pair binding at 40–45% loading reveals that Thy molecules are packed within the channels in a way that fulfill both the Woodward-Hoffmann and Schmidt rules, and upon UV irradiation, Thy molecules dimerize into Thy<>Thy. This study highlights the utility of accessible functional groups within the pores of MOFs, and their ability to ‘lock’ molecules in specific positions that can be subsequently dimerized upon light irradiation, extending the use of MOFs as nanoreactors for the synthesis of molecules that are otherwise challenging to isolate.
| Type: | Article |
|---|---|
| Title: | Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-019-09486-2 |
| Publisher version: | https://doi.org/10.1038/s41467-019-09486-2 |
| Language: | English |
| Additional information: | © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/ by/4.0/. |
| Keywords: | Bioinspired materials, Chemical biology, Metal–organic frameworks |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10075387 |
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