UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine

O'brien, F; Clapham, D; Krysiak, K; Batchelor, H; Field, P; Caivano, G; Pertile, M; ... Tuleu, C; + view all (2019) Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine. International Journal of Molecular Sciences , 20 (11) , Article 2688 (Special Issue: Paediatric Formulation: Design and Development). 10.3390/ijms20112688. Green open access

[thumbnail of ijms-20-02688.pdf]
Preview
Text
ijms-20-02688.pdf - Published Version

Download (1MB) | Preview

Abstract

The development of age-appropriate formulations should focus on dosage forms that can deliver variable yet accurate doses that are safe and acceptable to the child, are matched to his/her development and ability, and avoid medication errors. However, in the past decade, the medication needs of neonates have largely been neglected. The aim of this review is to expand on what differentiates the needs of preterm and term neonates from those of the older paediatric subsets, in terms of environment of care, ability to measure and administer the dose (from the perspective of the patient and carer, the routes of administration, the device and the product), neonatal biopharmaceutics and regulatory challenges. This review offers insight into those challenges posed by the formulation of medicinal products for neonatal patients in order to support the development of clinically relevant products.

Type: Article
Title: Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/ijms20112688
Publisher version: https://doi.org/10.3390/ijms20112688
Language: English
Additional information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/ licenses/by/4.0/).
Keywords: neonates; formulation; product development; formulation development; oral; parenteral; topical; inhaled; intra nasal; biopharmaceutics; administration; excipient; NICU; device; medication error; dosage form
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > VP: Research > Library Services
URI: https://discovery.ucl.ac.uk/id/eprint/10075385
Downloads since deposit
114Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item