O'brien, F;
Clapham, D;
Krysiak, K;
Batchelor, H;
Field, P;
Caivano, G;
Pertile, M;
... Tuleu, C; + view all
(2019)
Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine.
International Journal of Molecular Sciences
, 20
(11)
, Article 2688 (Special Issue: Paediatric Formulation: Design and Development). 10.3390/ijms20112688.
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Abstract
The development of age-appropriate formulations should focus on dosage forms that can deliver variable yet accurate doses that are safe and acceptable to the child, are matched to his/her development and ability, and avoid medication errors. However, in the past decade, the medication needs of neonates have largely been neglected. The aim of this review is to expand on what differentiates the needs of preterm and term neonates from those of the older paediatric subsets, in terms of environment of care, ability to measure and administer the dose (from the perspective of the patient and carer, the routes of administration, the device and the product), neonatal biopharmaceutics and regulatory challenges. This review offers insight into those challenges posed by the formulation of medicinal products for neonatal patients in order to support the development of clinically relevant products.
| Type: | Article |
|---|---|
| Title: | Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/ijms20112688 |
| Publisher version: | https://doi.org/10.3390/ijms20112688 |
| Language: | English |
| Additional information: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/ licenses/by/4.0/). |
| Keywords: | neonates; formulation; product development; formulation development; oral; parenteral; topical; inhaled; intra nasal; biopharmaceutics; administration; excipient; NICU; device; medication error; dosage form |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics UCL > Provost and Vice Provost Offices > VP: Research > Library Services |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10075385 |
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