Ganzevoort, W;
Thornton, JG;
Marlow, N;
Thilaganathan, B;
Arabin, B;
Prefumo, F;
Lees, C;
... TRUFFLE-study group; + view all
(2020)
Comparative analysis of the 2-year outcomes in the GRIT and TRUFFLE trials.
Ultrasound in Obstetrics and Gynaecology
, 55
(1)
pp. 68-74.
10.1002/uog.20354.
Preview |
Text
Marlow_uog.20354.pdf Download (960kB) | Preview |
Abstract
OBJECTIVE: To explore the influence on perinatal outcome of different fetal monitoring strategies for preterm fetal growth restriction (FGR). DESIGN: Cohort analysis of individual participant data from the Growth Restriction Intervention Study (GRIT) and Trial of Umbilical and Fetal Flow in Europe (TRUFFLE) studies. SETTING: European multi-centre trials. POPULATION: All women from GRIT (n=238) and TRUFFLE (n=503), randomized between 26 and 32 weeks. METHODS: Women were categorized according to their monitoring-intervention method: A. immediate delivery (from GRIT), B. delayed delivery using conventional cardiotocography (CTG, from GRIT), C. delayed delivery using computerized CTG only (cCTG, from GRIT), D delayed delivery using cCTG only (from TRUFFLE) and E. delayed delivery using cCTG and ductus venosus (DV) Doppler (from TRUFFLE). PRIMARY OUTCOME MEASURE: Survival without impairment at two years. RESULTS: Gestational age at delivery and birth weight were similar in both studies. Fetal death rate was similar between GRIT and TRUFFLE, but neonatal and late death were more frequent in GRIT (18% vs. 6%; p<0.01). The primary outcome was least common in groups A (70%; 95% confidence interval [CI] 61-78), and B (69%; 95% CI 57-82), and increased with more advanced monitoring in C (80%; 95% CI 68-91) and D (77%; 95% CI 70-84) and was highest in E (84%; 95% CI 80-89); (p trend <0.01). CONCLUSIONS: This analysis supports that fetal monitoring for early FGR can best be performed by the combination of cCTG and DV Doppler assessment. TRIAL REGISTRATION: GRIT ISRCTN41358726 and TRUFFLE ISRCTN56204499. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Comparative analysis of the 2-year outcomes in the GRIT and TRUFFLE trials |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/uog.20354 |
| Publisher version: | http://doi.org/10.1002/uog.20354 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. http://creativecommons.org/licenses/by-nc/4.0/ |
| Keywords: | Fetal growth restriction, cardiotocography, ductus venosus, monitoring, short term variation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10075281 |
Archive Staff Only
 |
View Item |
