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Early life pain—effects in the adult

Walker, S; (2019) Early life pain—effects in the adult. Current Opinion in Physiology , 11 pp. 16-24. 10.1016/j.cophys.2019.04.011. Green open access

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Abstract

Early life stress and injury can have long-term effects on nociceptive processing and the risk of persistent pain in later life. Neonates requiring prolonged intensive care, particularly those born extremely preterm, are at risk due both to immaturity at birth and exposure to tissue injury and pain from procedural interventions and surgery. This review will summarize clinical evaluations of pain experience and somatosensory function in preterm-born young adults; and highlight data from laboratory studies evaluating the potential for tissue injury in neonatal rodents to prime nociceptive processing and alter the response to subsequent injury in adulthood.

Type: Article
Title: Early life pain—effects in the adult
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cophys.2019.04.011
Publisher version: https://doi.org/10.1016/j.cophys.2019.04.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10075195
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