Walker, S;
(2019)
Early life pain—effects in the adult.
Current Opinion in Physiology
, 11
pp. 16-24.
10.1016/j.cophys.2019.04.011.
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Abstract
Early life stress and injury can have long-term effects on nociceptive processing and the risk of persistent pain in later life. Neonates requiring prolonged intensive care, particularly those born extremely preterm, are at risk due both to immaturity at birth and exposure to tissue injury and pain from procedural interventions and surgery. This review will summarize clinical evaluations of pain experience and somatosensory function in preterm-born young adults; and highlight data from laboratory studies evaluating the potential for tissue injury in neonatal rodents to prime nociceptive processing and alter the response to subsequent injury in adulthood.
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