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Dual-responsive Nanoparticles Based on Chitosan for Enhanced Breast Cancer Therapy

Xuejing, Z; Shiwei, N; Williams, G; Jianrong, W; Xia, C; Hong, Z; Li-Min, Z; (2019) Dual-responsive Nanoparticles Based on Chitosan for Enhanced Breast Cancer Therapy. Carbohydrate Polymers , 221 pp. 84-93. 10.1016/j.carbpol.2019.05.081. Green open access

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Abstract

In this study, we report a novel pH and temperature responsive paclitaxel-loaded drug delivery system based on chitosan and di(ethylene glycol) methyl ether methacrylate. This was functionalized with hyaluronic acid to permit active targeting of CD44-overexpressing human breast cancer cells. The resultant HA-CS-g-PDEGMA-PTX nanoparticles (NPs) have small and uniform sizes (˜170 nm), a high drug loading (13.6 ± 1.3%) and high encapsulation efficiency (76.2 ± 8.5%). Cell viability and confocal microscopy experiments demonstrated that the NPs could effectively target and kill MDA-MB-231 human breast cancer cells, but were much less toxic to healthy human umbilical vein endothelial cells. In vivo biodistribution studies in mice showed that the NPs accumulated in the tumor site, while free drug was distributed more widely and rapidly cleared from the body. Histopathological studies revealed that the NPs led to enhanced apoptosis in the tumor site, which resulted in reduced tumor growth. The NPs prepared in this work have great potential for the treatment of breast cancers, and further offer a platform with which to target other cancers.

Type: Article
Title: Dual-responsive Nanoparticles Based on Chitosan for Enhanced Breast Cancer Therapy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.carbpol.2019.05.081
Publisher version: https://doi.org/10.1016/j.carbpol.2019.05.081
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: hyaluronic acid, nanoparticles, dual-responsive, anticancer efficacy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10075157
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