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Anti-inflammatory activity of furosemide and spironolactone

Vaidya, JS; Jain, A; Diniz, RS; (1986) Anti-inflammatory activity of furosemide and spironolactone. Clinician , 50 (11) pp. 380-384. Green open access

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Abstract

Two diuretics - furosemide and spironolactone - were investigated for anti-inflammatory activity in two models of inflammation, namely, exudative phase (carrageenin-induced rat hind paw oedema) and proliferative phase (cotton pellet-induced granuloma in mice). Phe-nylbutazone, a non steroidal anti-inf lam-mator agent was used as a standard drug for comparison. In both the models of inflammation, furosemide showed statistically significant anti-inflammatory activity. Spironolactone, however, failed to exhibit significant anti-inflammatory activity in the model for acute inflammation though it was very effective in chronic inflammation.

Type: Article
Title: Anti-inflammatory activity of furosemide and spironolactone
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10075119
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