Rao, M;
Dodoo, E;
Zumla, A;
Maeurer, M;
(2019)
Immunometabolism and Pulmonary Infections: Implications for Protective Immune Responses and Host-Directed Therapies.
Frontiers in Microbiology
, 10
, Article 962. 10.3389/fmicb.2019.00962.
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Abstract
The biology and clinical efficacy of immune cells from patients with infectious diseases or cancer are associated with metabolic programming. Host immune- and stromal-cell genetic and epigenetic signatures in response to the invading pathogen shape disease pathophysiology and disease outcomes. Directly linked to the immunometabolic axis is the role of the host microbiome, which is also discussed here in the context of productive immune responses to lung infections. We also present host-directed therapies (HDT) as a clinically viable strategy to refocus dysregulated immunometabolism in patients with infectious diseases, which requires validation in early phase clinical trials as adjuncts to conventional antimicrobial therapy. These efforts are expected to be continuously supported by newly generated basic and translational research data to gain a better understanding of disease pathology while devising new molecularly defined platforms and therapeutic options to improve the treatment of patients with pulmonary infections, particularly in relation to multidrug-resistant pathogens.
| Type: | Article |
|---|---|
| Title: | Immunometabolism and Pulmonary Infections: Implications for Protective Immune Responses and Host-Directed Therapies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fmicb.2019.00962 |
| Publisher version: | https://doi.org/10.3389/fmicb.2019.00962 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Microbiology, lung infections, immunometabolism, inflammation, immunological memory, protective immune responses, MYCOBACTERIUM-TUBERCULOSIS INFECTION, T-CELL-ACTIVATION, ARYL-HYDROCARBON RECEPTOR, COLONY-STIMULATING FACTOR, CHAIN FATTY-ACIDS, LOW-DOSE ASPIRIN, NITRIC-OXIDE, IFN-GAMMA, CYTOMEGALOVIRUS-INFECTION, CHLAMYDIA-PNEUMONIAE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074863 |
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