Robertson, J;
Haas, CT;
Pele, LC;
Monie, TP;
Charalambos, C;
Parkes, M;
Hewitt, RE;
(2016)
Intestinal APCs of the endogenous nanomineral pathway fail to express PD-L1 in Crohn’s disease.
Scientific Reports
, 6
, Article 26747. 10.1038/srep26747.
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Abstract
Crohn’s disease is a chronic inflammatory condition most commonly affecting the ileum and colon. The aetiology of Crohn’s disease is complex and may include defects in peptidoglycan recognition, and/or failures in the establishment of intestinal tolerance. We have recently described a novel constitutive endogenous delivery system for the translocation of nanomineral-antigen-peptidoglycan (NAP) conjugates to antigen presenting cells (APCs) in intestinal lymphoid patches. In mice NAP conjugate delivery to APCs results in high surface expression of the immuno-modulatory molecule programmed death receptor ligand 1 (PD-L1). Here we report that NAP conjugate positive APCs in human ileal tissues from individuals with ulcerative colitis and intestinal carcinomas, also have high expression of PD-L1. However, NAP-conjugate positive APCs in intestinal tissue from patients with Crohn’s disease show selective failure in PD-L1 expression. Therefore, in Crohn’s disease intestinal antigen taken up by lymphoid patch APCs will be presented without PD-L1 induced tolerogenic signalling, perhaps initiating disease.
| Type: | Article |
|---|---|
| Title: | Intestinal APCs of the endogenous nanomineral pathway fail to express PD-L1 in Crohn’s disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/srep26747 |
| Publisher version: | https://doi.org/10.1038/srep26747 |
| Language: | English |
| Additional information: | © 2019 Springer Nature Publishing AG. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Antigen-presenting cells, Chronic inflammation, Crohn's disease, Mechanisms of disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074830 |
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