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CNS embryonal tumours: WHO 2016 and beyond

Pickles, JC; Hawkins, C; Pietsch, T; Jacques, TS; (2018) CNS embryonal tumours: WHO 2016 and beyond. Neuropathology and Applied Neurobiology , 44 (2) pp. 151-162. 10.1111/nan.12443. Green open access

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Abstract

Embryonal tumours of the central nervous system (CNS) present a significant clinical challenge. Many of these neoplasms affect young children, have a very high mortality and therapeutic strategies are often aggressive with poor long‐term outcomes. There is a great need to accurately diagnose embryonal tumours, predict their outcome and adapt therapy to the individual patient's risk. For the first time in 2016, the WHO classification took into account molecular characteristics for the diagnosis of CNS tumours. This integration of histological features with genetic information has significantly changed the diagnostic work‐up and reporting of tumours of the CNS. However, this remains challenging in embryonal tumours due to their previously unaccounted tumour heterogeneity. We describe the recent revisions made to the 4th edition of the WHO classification of CNS tumours and review the main changes, while highlighting some of the more common diagnostic testing strategies.

Type: Article
Title: CNS embryonal tumours: WHO 2016 and beyond
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nan.12443
Publisher version: https://doi.org/10.1111/nan.12443
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: atypical teratoid/rhabdoid tumour, embryonal tumour, embryonal tumour with multilayered rosettes, medulloblastoma, World Health Organisation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10074731
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