Esmail, H;
Lai, RP;
Lesosky, M;
Wilkinson, KA;
Graham, CM;
Coussens, AK;
Oni, T;
... Wilkinson, RJ; + view all
(2016)
Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography.
Nature Medicine
, 22
pp. 1090-1093.
10.1038/nm.4161.
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Abstract
Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
| Type: | Article |
|---|---|
| Title: | Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nm.4161 |
| Publisher version: | https://doi.org/10.1038/nm.4161 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | HIV infections, Infection, Translational research, Tuberculosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074640 |
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