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MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers

Thompson, A; Freund, P; Seif, M; Weiskopf, N; Friston, K; Fehlings, M; Curt, A; (2019) MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers. The Lancet Neurology 10.1016/S1474-4422(19)30138-3. (In press).

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MRI in traumatic SCI-THELANCETNEUROLOGY-D-18-00814R2 (3).pdf - Accepted version
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Abstract

Traumatic spinal cord injury (SCI) occurs when an external physical impact acutely damages the spinal cord and leads to permanent neurologic dysfunction, personal disability and social burden. Conventional MRI plays a crucial role in the diagnostic workup of SCI patients as it reveals extrinsic compression of the cord and disruption of the discoligamentous complex. Additionally, it can reveal macrostructural evidence of primary intramedullary damage such as haemorrhage, oedema, post-traumatic cystic cavities and tissue bridges. Quantitative MRI (qMRI), such as magnetisation transfer, MR relaxation mapping and diffusion imaging, enables the tracking of secondary changes across the neuraxis at the microstructural level. Both, conventional MRI and qMRI metrics, obtained early after SCI, are predictive of outcome. Thus, neuroimaging biomarkers may serve as surrogate endpoints for more efficient trials targeting acute and chronic SCI. The adoption of neuroimaging biomarkers in SCI centres may eventually lead to individualized patient care approaches.

Type: Article
Title: MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers
DOI: 10.1016/S1474-4422(19)30138-3
Publisher version: https://doi.org/10.1016/S1474-4422(19)30138-3
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10074621
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