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The proteostasis network provides targets for neurodegeneration

Newton, TM; Duce, JA; Bayle, ED; (2019) The proteostasis network provides targets for neurodegeneration. British Journal of Pharmacology , 176 (18) pp. 3508-3514. 10.1111/bph.14643. Green open access

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Abstract

The production, quality control, and degradation of proteins is a tightly controlled process necessary for cell health. In order to regulate this process cells rely upon a network of molecular chaperone proteins that bind misfolded proteins and help them fold correctly. In addition, some molecular chaperones can target terminally misfolded proteins for degradation. Neurons are particularly dependent upon this 'proteostasis' system, failures in which lead to neurodegenerative disease. In this review we identify opportunities for modulating molecular chaperone activity with small molecules, which could lower the burden of misfolded protein within neurons, reducing cell death and ameliorating the effects of neurodegeneration.

Type: Article
Title: The proteostasis network provides targets for neurodegeneration
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bph.14643
Publisher version: https://doi.org/10.1111/bph.14643
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10074507
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