Azadbakht, H;
Parkes, LM;
Haroon, HA;
Augath, M;
Logothetis, NK;
de Crespigny, A;
D'Arceuil, HE;
(2015)
Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex.
Cerebral Cortex
, 25
(11)
pp. 4299-4309.
10.1093/cercor/bhu326.
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Abstract
Diffusion magnetic resonance imaging (MRI) allows for the noninvasive in vivo examination of anatomical connections in the human brain, which has an important role in understanding brain function. Validation of this technique is vital, but has proved difficult due to the lack of an adequate gold standard. In this work, the macaque visual system was used as a model as an extensive body of literature of in vivo and postmortem tracer studies has established a detailed understanding of the underlying connections. We performed probabilistic tractography on high angular resolution diffusion imaging data of 2 ex vivo, in vitro macaque brains. Comparisons were made between identified connections at different thresholds of probabilistic connection “strength,” and with various tracking optimization strategies previously proposed in the literature, and known connections from the detailed visual system wiring map described by Felleman and Van Essen (1991; FVE91). On average, 74% of connections that were identified by FVE91 were reproduced by performing the most successfully optimized probabilistic diffusion MRI tractography. Further comparison with the results of a more recent tracer study ( Markov et al. 2012) suggests that the fidelity of tractography in estimating the presence or absence of interareal connections may be greater than this.
| Type: | Article |
|---|---|
| Title: | Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/cercor/bhu326 |
| Publisher version: | https://doi.org/10.1093/cercor/bhu326 |
| Language: | English |
| Additional information: | © The Author 2015. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | diffusion imaging, macaque, tractography, validation, visual cortex |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074458 |
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