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Neuroplasticity and aphasia treatments: new approaches for an old problem

Crosson, B; Rodriguez, AD; Copland, D; Fridriksson, J; Krishnamurthy, LC; Meinzer, M; Raymer, AM; ... Leff, AP; + view all (2019) Neuroplasticity and aphasia treatments: new approaches for an old problem. Journal of Neurology, Neurosurgery and Psychiatry 10.1136/jnnp-2018-319649. Green open access

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Abstract

Given the profound impact of language impairment after stroke (aphasia), neuroplasticity research is garnering considerable attention as means for eventually improving aphasia treatments and how they are delivered. Functional and structural neuroimaging studies indicate that aphasia treatments can recruit both residual and new neural mechanisms to improve language function and that neuroimaging modalities may hold promise in predicting treatment outcome. In relatively small clinical trials, both non-invasive brain stimulation and behavioural manipulations targeting activation or suppression of specific cortices can improve aphasia treatment outcomes. Recent language interventions that employ principles consistent with inducing neuroplasticity also are showing improved performance for both trained and novel items and contexts. While knowledge is rapidly accumulating, larger trials emphasising how to select optimal paradigms for individualised aphasia treatment are needed. Finally, a model of how to incorporate the growing knowledge into clinical practice could help to focus future research.

Type: Article
Title: Neuroplasticity and aphasia treatments: new approaches for an old problem
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2018-319649
Publisher version: http://dx.doi.org/10.1136/jnnp-2018-319649
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: aphasia, brain mapping, functional imaging, rehabilitation, stroke
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10074427
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