Palombo, M;
Shemesh, N;
Ianus, A;
Alexander, D;
Zhang, H;
(2018)
Abundance of cell bodies can explain the stick model’s failure in grey matter at high bvalue.
In: Miller, KL and Port, JD, (eds.)
Proceedings of the Joint Annual Meeting ISMRM-ESMRMB 2018.
ISMRM (International Society for Magnetic Resonance in Medicine): Concord, CA, USA.
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Abstract
This work investigates the validity of the stick model used in diffusion-weighted MRI for modelling cellular projections in brain tissue. We hypothesize that the model will fail to describe the signals from grey matter due to an abundance of cell bodies. Using high b-value (≥3 ms/µm ) data from rat and human brain, we show that the assumption fails for grey matter. Using diffusion simulation in realistic digital models of neurons/glia, we demonstrate the breakdown of the assumption can be explained by the presence of cell bodies. Our findings suggest that high b-value data may be used to probe cell bodies.
| Type: | Proceedings paper |
|---|---|
| Title: | Abundance of cell bodies can explain the stick model’s failure in grey matter at high bvalue |
| Event: | Joint Annual Meeting ISMRM-ESMRMB 2018, 16-21 June 2018, Paris, France |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.ismrm.org/18m/ |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074387 |
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