Foxall, E;
Pipili, A;
Jones, GE;
Wells, CM;
(2016)
Significance of kinase activity in the dynamic invadosome.
European Journal of Cell Biology
, 95
(11)
pp. 483-492.
10.1016/j.ejcb.2016.07.002.
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Abstract
Invadosomes are actin rich protrusive structures that facilitate invasive migration in multiple cell types. Comprised of invadopodia and podosomes, these highly dynamic structures adhere to and degrade the extracellular matrix, and are also thought to play a role in mechanosensing. Many extracellular signals have been implicated in invadosome stimulation, activating complex signalling cascades to drive the formation, activity and turnover of invadosomes. While the structural components of invadosomes have been well studied, the regulation of invadosome dynamics is still poorly understood. Protein kinases are essential to this regulation, affecting all stages of invadosome dynamics and allowing tight spatiotemporal control of their activity. Invadosome organisation and function have been linked to pathophysiological states such as cancer invasion and metastasis; therapeutic targeting of invadosome regulatory components is thus warranted. In this review, we discuss the involvement of kinase signalling in every stage of the invadosome life cycle and evaluate its significance.
| Type: | Article |
|---|---|
| Title: | Significance of kinase activity in the dynamic invadosome |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ejcb.2016.07.002 |
| Publisher version: | https://doi.org/10.1016/j.ejcb.2016.07.002 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Cell Biology, Invadopodia, Podosomes, Kinases, Src, Tyrosine phosphorylation, Actin, CANCER-CELL INVASION, HUMAN BREAST-CANCER, WISKOTT-ALDRICH-SYNDROME, FOCAL ADHESION KINASE, EXTRACELLULAR-MATRIX DEGRADATION, NUCLEOTIDE EXCHANGE FACTOR, PROTEIN-TYROSINE KINASES, AORTIC ENDOTHELIAL-CELLS, SMOOTH-MUSCLE-CELLS, INVADOPODIA FORMATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074218 |
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