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Prospects for reconsolidation-focused treatments of substance use and anxiety-related disorders

Paulus, DJ; Kamboj, SK; Das, RK; Saladin, ME; (2019) Prospects for reconsolidation-focused treatments of substance use and anxiety-related disorders. Current Opinion in Psychology , 30 pp. 80-86. 10.1016/j.copsyc.2019.03.001. Green open access

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Abstract

Memories are often conceptualized as permanent entities; however, retrieval of memories via stimulus prompts can return them to an active state, which initiates a period of lability before the memories are reconsolidated into long-term storage. Importantly, during this period, memories can be disrupted/altered. A growing body of work has focused on translating animal and experimental science into reconsolidation-based interventions for clinical disorders maintained by maladaptive memories. Interventions targeting reward-based and fear-based memories undergirding substance use and anxiety-related disorders, respectively, have shown significant potential. There are several promising pharmacological agents and behavioral approaches that have been used to therapeutically target memory reconsolidation. Here, we discuss the current state of science with special emphasis on the clinical utility of these approaches.

Type: Article
Title: Prospects for reconsolidation-focused treatments of substance use and anxiety-related disorders
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.copsyc.2019.03.001
Publisher version: https://doi.org/10.1016/j.copsyc.2019.03.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10073993
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