Sagar, R;
Götherström, C;
David, AL;
Westgren, M;
(2019)
Fetal stem cell transplantation and gene therapy.
Best Practice & Research Clinical Obstetrics & Gynaecology
, 58
pp. 142-153.
10.1016/j.bpobgyn.2019.02.007.
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Abstract
The present chapter summarizes our current knowledge on fetal stem cell and gene therapy. It focuses on these therapeutic alternatives in regard to past experiences and ongoing and planned studies in humans. Several methodological challenges are discussed that may have wide implications on how these methods could be introduced in clinical practices. Although still promising, the methods are afflicted with very special requirements not least in regard to safety and ethical questions. Furthermore, careful monitoring and extended follow-up of the child and his/hers mother who receive prenatal stem cell or gene treatments are of outmost importance. Taken these prerequisites into consideration, it is natural that this type of experimental fetal therapies requires collaboration between different disciplinaries and institutions within medicine.
| Type: | Article |
|---|---|
| Title: | Fetal stem cell transplantation and gene therapy |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bpobgyn.2019.02.007 |
| Publisher version: | https://doi.org/10.1016/j.bpobgyn.2019.02.007 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | A-thalassemia, Fetal therapy, Gene therapy, Hematopoetic stem cell, Mesenchymal stem cells, Osteogenesis imperfecta |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10073930 |
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