UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Fetal stem cell transplantation and gene therapy

Sagar, R; Götherström, C; David, AL; Westgren, M; (2019) Fetal stem cell transplantation and gene therapy. Best Practice & Research Clinical Obstetrics & Gynaecology , 58 pp. 142-153. 10.1016/j.bpobgyn.2019.02.007. Green open access

[img]
Preview
Text
David Final YBEOG.pdf - Accepted version

Download (740kB) | Preview

Abstract

The present chapter summarizes our current knowledge on fetal stem cell and gene therapy. It focuses on these therapeutic alternatives in regard to past experiences and ongoing and planned studies in humans. Several methodological challenges are discussed that may have wide implications on how these methods could be introduced in clinical practices. Although still promising, the methods are afflicted with very special requirements not least in regard to safety and ethical questions. Furthermore, careful monitoring and extended follow-up of the child and his/hers mother who receive prenatal stem cell or gene treatments are of outmost importance. Taken these prerequisites into consideration, it is natural that this type of experimental fetal therapies requires collaboration between different disciplinaries and institutions within medicine.

Type: Article
Title: Fetal stem cell transplantation and gene therapy
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bpobgyn.2019.02.007
Publisher version: https://doi.org/10.1016/j.bpobgyn.2019.02.007
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: A-thalassemia, Fetal therapy, Gene therapy, Hematopoetic stem cell, Mesenchymal stem cells, Osteogenesis imperfecta
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10073930
Downloads since deposit
133Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item