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A call for a better understanding of causation in cell biology

Bizzarri, M; Brash, DE; Briscoe, J; Grieneisen, VA; Stern, CD; Levin, M; (2019) A call for a better understanding of causation in cell biology. Nature Reviews Molecular Cell Biology , 20 (5) pp. 261-262. 10.1038/s41580-019-0127-1. Green open access

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Abstract

What does it mean to say that event X caused outcome Y in biology? Explaining the causal structure underlying the dynamic function of living systems is a central goal of biology. Transformative advances in regenerative medicine and synthetic bioengineering will require efficient strategies to cause desired system-level outcomes. We present a perspective on the need to move beyond the classical ‘necessary and sufficient’ approach to biological causality.

Type: Article
Title: A call for a better understanding of causation in cell biology
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41580-019-0127-1
Publisher version: https://doi.org/10.1038/s41580-019-0127-1
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10073923
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