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Upfront Matched Unrelated Donor Transplantation in Aplastic Anemia

Clesham, K; Dowse, R; Samarasinghe, S; (2018) Upfront Matched Unrelated Donor Transplantation in Aplastic Anemia. Hematology/Oncology Clinics of North America , 32 (4) pp. 619-628. 10.1016/j.hoc.2018.03.004. Green open access

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Abstract

Idiopathic severe aplastic anemia (SAA) is a rare condition, and hemopoietic stem cell transplantation (HSCT) remains the only curative therapy; HSCT is considered first-line treatment in patients less than 35 years old with SAA with a matched sibling donor (MSD); Current best practice is less clear in those without an MSD. Immunosuppressive therapy (IST) has traditionally been thought of as first-line treatment in those without an MSD; however, there remains a significant risk of relapse and clonal evolution; Outcomes following matched unrelated donor (MUD) HSCT in SAA have improved because of advances in the development of high-resolution HLA typing, developments in supportive care, and implementation of novel conditioning regimens; After careful discussion with the patient and parents, MUD HSCT could be considered first-line treatment in selected patients.

Type: Article
Title: Upfront Matched Unrelated Donor Transplantation in Aplastic Anemia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.hoc.2018.03.004
Publisher version: https://doi.org/10.1016/j.hoc.2018.03.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Aplastic anemia, Hemopoietic stem cell transplantation (HSCT), Matched sibling donor, Matched unrelated donor
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/10073884
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