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Determining Stroke Onset Time Using Quantitative MRI: High Accuracy, Sensitivity and Specificity Obtained from Magnetic Resonance Relaxation Times

McGarry, BL; Rogers, HJ; Knight, MJ; Jokivarsi, KT; Gröhn, OHJ; Kauppinen, RA; (2016) Determining Stroke Onset Time Using Quantitative MRI: High Accuracy, Sensitivity and Specificity Obtained from Magnetic Resonance Relaxation Times. Cerebrovascular Diseases Extra , 6 (2) pp. 60-65. 10.1159/000448814. Green open access

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Abstract

Many ischaemic stroke patients are ineligible for thrombolytic therapy due to unknown onset time. Quantitative MRI (qMRI) is a potential surrogate for stroke timing. Rats were subjected to permanent middle cerebral artery occlusion and qMRI parameters including hemispheric differences in apparent diffusion coefficient, T 2-weighted signal intensities, T 1 and T 2 relaxation times (qT 1, qT 2) and f1, f2 and Voverlap were measured at hourly intervals at 4.7 or 9.4 T. Accuracy and sensitivity for identifying strokes scanned within and beyond 3 h of onset was determined. Accuracy for Voverlap, f2 and qT 2 (>90%) was significantly higher than other parameters. At a specificity of 1, sensitivity was highest for Voverlap (0.90) and f2 (0.80), indicating promise of these qMRI indices in the clinical assessment of stroke onset time.

Type: Article
Title: Determining Stroke Onset Time Using Quantitative MRI: High Accuracy, Sensitivity and Specificity Obtained from Magnetic Resonance Relaxation Times
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000448814
Publisher version: https://doi.org/10.1159/000448814
Language: English
Additional information: This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. https://creativecommons.org/licenses/by-nc-nd/3.0/
Keywords: Quantitative MRI · Ischaemia · Wake-up stroke
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
URI: https://discovery.ucl.ac.uk/id/eprint/10073792
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