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Glass microparticle- versus microsphere-filled experimental dental adhesives

Abou Neel, EA; Kiani, A; Valappil, SP; Mordan, NM; Baek, SY; Zakir Hossain, KM; Felfel, RM; ... Knowles, JC; + view all (2019) Glass microparticle- versus microsphere-filled experimental dental adhesives. Journal of Applied Polymer Science , 136 (32) , Article 47832. 10.1002/app.47832. Green open access

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Abstract

This study aimed to formulate antibacterial dental adhesives. Phosphate‐substituted methacrylate adhesives were modified with 0–20 wt % copper‐doped glass microparticles. Two shapes of microparticles were used: regular shaped (microspheres) and irregular shaped (microparticles). The morphology/composition, roughness, monomer conversion (DC%), thermogravimetric analysis, and antibacterial action against S. mutans and P. aeruginosa and ion release were investigated. The results showed that microspheres produced adhesives with a relatively smoother surface than microparticles did. The DC% of adhesives increased with increasing glass filler content. Filled adhesives showed polymer decomposition at ~315 °C and glass melting at 600–1000 °C. The weight loss percent of adhesives decreased with increasing weight percent of fillers. Glass microparticles at 0–20 wt % significantly increased the antibacterial action of adhesives against both bacteria. Glass microspheres at 0–5 wt % significantly increased the antibacterial action of adhesives against both bacteria. Only 20 wt % microparticle‐filled adhesive showed an inhibition zone similar to tobramycin (positive control). Microparticle‐filled adhesives (with >5 wt % filler) significantly reduced S. mutans more than their microsphere counterparts. Microsphere‐filled adhesives (with ≤5 wt % filler) significantly reduced P. aeruginosa more than their microparticle counterparts. Microsphere‐filled adhesives showed higher Cu release than their microparticle counterparts. Accordingly, phosphate‐substituted methacrylate filled with glass could be used as an antibacterial adhesive.

Type: Article
Title: Glass microparticle- versus microsphere-filled experimental dental adhesives
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/app.47832
Publisher version: https://doi.org/10.1002/app.47832
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: adhesives, biomaterials, biomedical applications
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10073720
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