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The effects of the size of a boiling bubble on lesion production in boiling histotripsy

Pahk, KJ; De Andrade, MO; Kim, H; Saffari, N; (2019) The effects of the size of a boiling bubble on lesion production in boiling histotripsy. In: Proceedings of the 17th annual Anglo-French Physical Acoustics Conference (AFPAC). IOP Publishing: Bristol, UK. Green open access

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Abstract

Boiling histotripsy employs a number of millisecond-long High Intensity Focused Ultrasound (HIFU) pulses with high acoustic peak pressures at the HIFU focus to mechanically fractionate soft tissue. Studies have shown the mechanisms underpinning this tissue fractionation process; however, the question of how HIFU exposure conditions affect lesion formation still remains unclear. In the present work, a high-speed camera and a passive cavitation detection (PCD) system were used to investigate the dynamics of bubbles induced and the corresponding mechanical damage generated in optically transparent tissue-mimicking phantoms with two different boiling histotripsy exposure conditions (1. P + = 85.4 MPa, P - = - 15.6 MPa; 2. P + = 71.5 MPa, P - = - 13.4 MPa at focus). Our results clearly showed that there is a positive relationship between the size of a boiling bubble and the lesion dimension. At P + = 85.4 MPa and P - = - 15.6 MPa, a relatively larger boiling bubble was, for instance, produced at the focus in the gel phantom followed by the presence of a wider cavitation cluster progressing toward the HIFU transducer, resulting in the formation of a larger lesion compared to that with P + = 71.5 MPa and P - = - 13.4 MPa.

Type: Proceedings paper
Title: The effects of the size of a boiling bubble on lesion production in boiling histotripsy
Event: 17th annual Anglo-French Physical Acoustics Conference (AFPAC), 17-19 January 2018, Selsdon, Surrey
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/1742-6596/1184/1/012007
Publisher version: https://iopscience.iop.org/issue/1742-6596/1184/1
Language: English
Additional information: Copyright © The Author 2019. Published under licence by IOP Publishing Ltd. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10073704
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