UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Autophagy in periodontal disease: Evidence from a literature review

Lorenzo-Pouso, AI; Castelo-Baz, P; Pérez-Sayáns, M; Lim, J; Leira, Y; (2019) Autophagy in periodontal disease: Evidence from a literature review. Archives of Oral Biology , 102 pp. 55-64. 10.1016/j.archoralbio.2019.03.029. Green open access

[img]
Preview
Text
Leira Feijoo manuscript arch oral biol rev yago.pdf - Accepted version

Download (595kB) | Preview

Abstract

Objective To summarize evidence and data relating to the implications of autophagy in periodontal disease (PD) and to describe potential nutraceuticals or pharmaceuticals that could modulate this cell death subtype. Design Literature searches of various electronic databases (Medline via PubMed, SCOPUS, Web of Science, and EMBASE) using appropriate keywords (e.g., periodontal disease, periodontitis, alveolar bone loss, periodontal infection, tooth loss, autophagy, programmed cell death, and type 2 cell death) were performed. Then, a comprehensive literature review of the current understanding of this link was elaborated. Results Autophagy plays a pivotal role in PD, and its regulation seems to be an interesting avenue for future periodontal research, according to several in vivo and in vitro reports. Conclusion Today’s research has ascertained the role of autophagy in PD, especially its role in the host’s defence against periodontal disease drivers. A bulk of the research recognised several pharmaceuticals and nutraceuticals that could potentially modulate this kind of cell death and serve as useful therapies. However, further research is warranted to reach a clinical translation, which could help in the discovery of novel host modulation therapies for PD.

Type: Article
Title: Autophagy in periodontal disease: Evidence from a literature review
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.archoralbio.2019.03.029
Publisher version: https://doi.org/10.1016/j.archoralbio.2019.03.029
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: autophagy; periodontal disease; disease prevention; molecular targets; redox regulation; cell fate.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10073637
Downloads since deposit
113Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item