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Clustering superparamagnetic iron oxide nanoparticles produces organ-targeted high-contrast magnetic resonance images

Hobson, NJ; Weng, X; Siow, B; Veiga, C; Ashford, M; Thanh, NT; Schätzlein, AG; (2019) Clustering superparamagnetic iron oxide nanoparticles produces organ-targeted high-contrast magnetic resonance images. Nanomedicine , 14 (9) pp. 1135-1152. 10.2217/nnm-2018-0370. Green open access

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Abstract

AIM: Superparamagnetic iron oxide nanoparticles (SPIONs) have been used as magnetic resonance imaging (MRI) contrast agents; however, a number of T2-weighted imaging SPIONs have been withdrawn due to their poor clinical contrast performance. Our aim was to significantly improve SPION T2-weighted MRI contrast by clustering SPIONs within novel chitosan amphiphiles. METHODS: Clustering SPIONs was achieved by encapsulation of hydrophobic-coated SPIONs with an amphiphilic chitosan polymer (GCPQ). RESULTS: Clustering increases the spin-spin (r2) to spin-lattice (r1) relaxation ratio (r2/r1) from 3.0 to 79.1, resulting in superior contrast. Intravenously administered clustered SPIONs accumulated only in the liver and spleen; with the reduction in T2 relaxation confined, in the liver, to the extravascular space, giving clear MRI images of the liver vasculature.

Type: Article
Title: Clustering superparamagnetic iron oxide nanoparticles produces organ-targeted high-contrast magnetic resonance images
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/nnm-2018-0370
Publisher version: https://doi.org/10.2217/nnm-2018-0370
Language: English
Additional information: © 2019 Ijeoma Uchegbu & all co-authors. This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit (http://creativecommons.org/licenses/by/4.0/).
Keywords: GCPQ, MRI contrast agent, SPIONs, chitosan amphiphile, micelle, superparamagnetic iron oxide nanoparticles
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/10073544
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