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The Cerebrospinal Fluid in Multiple Sclerosis

Deisenhammer, F; Zetterberg, H; Fitzner, B; Zettl, UK; (2019) The Cerebrospinal Fluid in Multiple Sclerosis. [Review]. Frontiers in Immunology , 10 , Article 726. 10.3389/fimmu.2019.00726. Green open access

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Abstract

Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria due to its good diagnostic accuracy and increasing issues with misdiagnosis of MS based on over interpretation of neuroimaging results. The hallmark of MS-specific changes in CSF is the detection of oligoclonal bands (OCB) which occur in the vast majority of MS patients. Lack of OCB has a very high negative predictive value indicating a red flag during the diagnostic work-up, and alternative diagnoses should be considered in such patients. Additional molecules of CSF can help to support the diagnosis of MS, improve the differential diagnosis of MS subtypes and predict the course of the disease, thus selecting the optimal therapy for each patient.

Type: Article
Title: The Cerebrospinal Fluid in Multiple Sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fimmu.2019.00726
Publisher version: https://doi.org/10.3389/fimmu.2019.00726
Language: English
Additional information: Copyright © 2019 Deisenhammer, Zetterberg, Fitzner and Zettl. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: CSF (cerebrospinal fluid), biomarker, multiple sclerosis, oligoclonal band (OCB), neurofilament light (NfL)
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10073452
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